The equation
\[x^4+y^4=z^2\]
  has no integer solutions.Proof
Suppose
\[x_1, \; y_1, \; z_1 \]
  is a solution. Suppose  \[gcd(x, \; y)=d \gt 1\]
  then   \[x^4+y^4=z^2 \rightarrow (dx')^4+(yd')^4=z^2 \rightarrow d^2 | z\]
  and   \[gcd(x', \; y' )=1\]
. We  can assume therefore that  \[gcd(x', \; y' )=1\]
. By writing the equation as  \[(x_1^2)^2+(y_1^2)^2=z_1^2\]
. (Pythagoras) we can take  \[x_1^2, \; y_1^2, \; z_1\]
  as Pythagorean Triples,  \[x_1=2mn,, y^2_1=m^2-n^2\]
, where  \[gcd(m, \; n)=1, \; m \gt n /gt 0\]
, and  \[m, \; n\]
  have opposite polarity.  \[m, \; n\]
  must be odd and even respectively since if the other way round then  \[(2k)^2-(2j+1)^2=4k^2-4j^2-4j-1 \equiv 3 \; (mod \; 4)\]
  but any square number is equal to 0 or 1 modulo 4.Putting
\[m=2r\]
  the equation for  \[x_1\]
  becomes  \[\( \frac{x_1}{2} \)^2=mr\]
  where  \[m\]
  and  \[r= \frac{n}{2}\]
  are relatively prime, hence  \[m, \; r\]
  are both square numbers. Put  \[m=s^2, \; r=t^2\]
>From the equation
\[y_2^2=m^2-n^2\]
   \[(y_1, \; m, \; n)\]
  is a Pythagorean triple so  \[n=2uv, \; y_1=u^2-v^2, \; m=u^2+v^2\]
 where  \[u, \; v\]
  are relatively prime integers off opposite polarity with  \[u \gt v\]
.Now
\[n=2r=2t^2\]
  so the first of these equations becomes  \[uv=t^2\]
. It follows that  \[u, \; v\]
  are each square numbers say  \[u=x_2^2, v=y_2^2\]
  and substituting into  \[m=u^2+v^2\]
   gives  \[x^2_2+y^2_2=m=s^2 \; ({}=z^2_2)\]
  say. This solution satisfies  \[0 \lt z_2=s \le m \lt m^2+n^2=z_1\]
.Hence a smaller solution exists, which is impossible and the proof is complete.