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The Wronskian of functions  
\[f,g\]
  at a point  
\[x_0\]
  is the determinant of the matrix
\[ W(f,g,x_0)= \left| \begin{array}{cc} f(x_0) & g(x_0) \\ f'(x_0) & g'(x_0) \end{array} \right| =f(x_0)g'(x_0)-g(x_0)f'(x_0)\]

Typically we consider the Wronskian when analysing the solutions of differential equations. Suppose we have the solutions  
\[f,g\]
  to a differential equation. If the Wronskian is zero at some point then the solutions are dependent.
Example:  
\[f(x)=sin x , \: g(x)=cos x\]
  are solutions to the equation  
\[y''+y=0\]

\[ W(f,g)= \left| \begin{array}{cc} sin x & cos x \\ cos x & -sin x \end{array} \right| =-cos^2 x - sin^2 x=-1\]

Hence  
\[sin x, \: cos x\]
  are independent or fundamental solutions.